Aseem Kumar, PhD
NOSM University |
| Professor, Biomolecular Sciences Ph.D. Program Professor, Department of Chemistry and Biochemistry Professor, Department of Biology Professor, Medical Sciences Division |
Education/Training
2009-present |
Full Professor Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University |
2006-2008 |
Associate Professor Canada Research Chair in Biomolecular Science (2003-2009) Director, Biomolecular Sciences Ph.D. Programme (2003-2009) Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University |
2003-2005 |
Assistant Professor Canada Research Chair in Biomolecular Science Director, Biomolecular Sciences Ph.D. Programme Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University |
1997-2002 |
Assistant Professor of Medicine Faculty, Division of Cardiovascular Disease and Critical Care Medicine and Department of Immunology/Microbiology Rush-Presbyterian-St. Luke’s Medical Center and University |
1995-1997 |
Cleveland Clinic Foundation Research Fellow Supervisor: George R. Stark |
1992-1997 |
University of Toronto, Ph.D. Faculty of Medicine Dept. of Molecular and Medical Genetics Supervisor: Dr. Bryan R. G. Williams |
1990-1992 |
University of Toronto, M.Sc. Faculty of Medicine Dept. of Molecular and Medical Genetics |
1983-1988 |
University of Toronto, B.Sc. Honours Faculty of Arts and Science Specialist Programme in Molecular Genetics and Biology Major Programme in Human Biology Minor Programme in Physiology |
Research Projects
Identification and Characterization of Sepsis Molecular Signaling Pathways
| Sepsis and septic shock represent the overwhelming response to infection. Approximately 800,000 cases of sepsis are admitted every year to hospitals in the North America and despite aggressive antibiotics and supportive care, over 200,000 patients per year succumb to this disorder. Sepsis and sepsis-associated multiple organ failure are the leading cause of death in intensive care units of the developed world and claim over 500,000 lives per year world wide. We are characterizing new initiators and mediators of sepsis and septic shock. These pathways and process include: cytokine signaling, transcription factor modulation, apoptosis, bacterial DNA and RNA signaling and characterization of global gene expression patterns that occur during the disease. To examine these signaling events we have developed a tissue culture model and a mouse model of sepsis and septic shock. We are also studying tissues from spontaneous human sepsis and septic shock. We are developing novel proteomic sepsis diagnostic technologies. |
Awards
| Canada Research Chair, Ontario Distinguished Research Award, International Society for Interferon and Cytokine Research Young Investigator Award, Cleveland Clinic Foundation Young Investigator Award, Cleveland Clinic Foundation Lower Award for Original Research Paper, Gold Duke of Edinburgh Award. Published in Journals that Include: Science, Nature Communications, EMBO J., PNAS, JBC, NAR, BBRC, BMC Medical Genomics, European Respiratory J., Chest, Critical Care Medicine, International Journal of Clinical and Experimental Medicine, Journal of Thoracic Disease. Career Funds Held: NIH, CRC, CIHR, CFI, NSERC, OIT, ORDCF, FedNor, MITACS. |
Selected Publications
| 1. Michael N. Rutherford, Aseem Kumar, Ahuva Nissim, Judith Chebath and Bryan R.G. Williams. The Murine 2-5A Synthetase Locus: Three Distinct Transcripts From Two Linked Genes. Nucleic Acids Research, Vol. 19, 1917-1924, #8, 1991.
2. Gengsheng Feng, Karen Chong, Aseem Kumar and Bryan R.G. Williams. Identification of dsRNA Binding Domains of the Interferon Induced Protein Kinase. Proc. Natl. Acad. Sci. USA, Vol. 89,5447-5451, June 1992. 3. Aseem Kumar, Jaharul S. Haque, Judith Lacoste, John Hiscott and Bryan R.G.Williams. The dsRNA-Dependent Protein Kinase, PKR, Activates Transcription Factor NF-B by Phosphorylating IB. Proc. Natl. Acad. Sci. USA, Vol. 91, 6288-6292, July 5, 1994. 4. A. Maran, R.K. Maitra, A.Kumar, B. Dong, W. Xiao, B.R.G. Williams, P.F. Torrence and R.H. Silverman. Blockage of NF-B Signaling By Selective Ablation of an mRNA Target by 2-5A-Antisense Chimeras. Science, Vol. 265, 789-792, August 5, 1994. 5. Yi-Li Yang, Luiz Reis, Jovin Pavlovic, Adriano Aguzzi, Reinhold Schafer, Aseem Kumar, Bryan R.G. Williams, Michel Auget and Charles Weissmann. Deficient Signalling in Mice Devoid of Double-stranded RNA-dependent Protein Kinase, PKR. EMBO J. Vol. 14, no. 24, 6095-6106, December 15, 1995. 6. Paul F. Torrence, Wei Xiao, Guiying Li, Shahrzad Khamnei, Krystyna Lesiak, Avudaiappan Maran, Ratan Maitra, Aseem Kumar, Beihua Dong, Bryan R. G. Williams and Robert H. Silverman. Targeting RNA for Degradation with a (2′,5′)-oligoadenylate Antisense Chimera. Nucleosides and Nucleotides, 14(3-5), 1073-1076, 1995. 7. Jaharul S. Haque, Heiko van der Kuip, Aseem Kumar, Walter E. Aulitzky, Michael N. Rutherford, Christopher Huber, Thomas Fischer, and Bryan R.G. Williams. Overexpression of Mouse p140-Subunit of Replication Factor C Accelerates Cellular Proliferation. Cell Growth and Differentiation 7,319-326, March 1996. 8. Michael Rutherford, Aseem Kumar, Benoit Coulombe, Dan Skup, Dave Carver and Bryan R.G. Williams. Intracellular Interferon Constituitively Activates ISGF3 and Confers Resistance to EMC Viral Infection. Journal of IFN and Cytokine Research 16, 507-510, July 1996. [The first two authors contributed equally to the paper and should be considered as first co-authors] 9. Michael Rutherford, Aseem Kumar, Jaharul S. Haque and Bryan R.G. Williams. Proto-oncogene Ets-1 Specifically Binds the ISRE of 2-5A Synthetase. Journal ofIFN and Cytokine Research 17, 1-10, 1997. [The first two authors contributed equally to the paper and should be considered as first co-authors] 10. Aseem Kumar, Yi-li Yang, Vincenzo Flati, Sandy Der, Suzanne Kadereit, Jaharul Haque, Amitabha Deb, Luiz Reis, Charles Weissmann and Bryan R.G. Williams. Deficient Cytokine Signaling in Mouse Embryo Fibroblasts with a Targeted Deletion in the PKR Gene. EMBO J. 16, 406-416, January 15, 1997. 11. Aseem Kumar, Mairead Commane, Thomas Flickinger, Curt Horbath, and George R. Stark. Defective TNF--Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases. Science, 278, 1630-1632, November 28, 1997. News and Views, 1541, ibid. Perspective, 1578-1579, ibid. 12. Xiao Rui Li, Anita Chong, Jianming Wu, Kenneth A. Roebuck, Aseem Kumar, Joseph E. Parrillo, Ulf R. Rapp, Robert P. Kimberly, James W. Williams and Xiulong Xu. Transcriptional Regulation of Fas Gene Expression by GA Binding Protein (GABP) and AP1 in T Cell Antigen Receptor (TCR)/CD3 Complex-Stimulated T Cells. J. Biol. Chem. 274, 35203-35210, December 3, 1999. 13. Ping Jiang, Aseem Kumar, Joseph E. Parrillo, Laurie A. Dempsey, Jeffrey L. Platt, Richard A. Prinz, Xiulong Xu. Transcriptional regulation of heparanase 1 gene expression in thyroid neoplastic cell lines by Sp1. J. Biol. Chem. 277: 8989-8998, March 15, 2002. 14. Bhanu Paladugu, Anand Kumar, Joseph E. Parrillo, Sandy Der, Jailan Osman, Joel Mensing, Lisa Falvo, Xiulong Xu and Aseem Kumar. Bacterial DNA and RNA Induce Rat Cardiac Myocyte Contraction Depression In-Vitro. Shock Journal 21(4):364-369, April 2004. 15. Chilakamarti V. Ramana, Aseem Kumar and Richard Enlow. STAT1-independent Induction of SOCS-3 by Interferon- is Mediated by Activated STAT3 in Mouse Embryo Fibroblasts. Biochemical and Biophysical Research Communications 327:727-733, 2005. 16. Aseem Kumar, Anand Kumar, Xiulong Xu and Joseph E. Parrillo.Human Serum Derived from Patients with Septic Shock Activates Transcription Factors STAT1, IRF1, NF-B and Induces Apoptosis in Human Cardiac Myocytes. J. Biol. Chem. 280:42619-42626, Dec. 2005. 17. Anand Kumar, Bhanu Paladugu, Cameron Haery, Aseem Kumar, Simon Symeoneides, Gordon Trenholme, Joanne Sandelski, Steve Opal and Joseph E. Parrillo. Duration of Hypotention Prior to Antibiotic Administration is a Critical Determinant of Outcome in a Murine Model of E. coli Septic Shock. Major Article in the Journal of Infectious Diseases 193:251-258, 2006. 18. Anand Kumar, Kenneth E. Wood, Robert Suppes, Joseph E. Parrillo, Daniel Feinstein, Satendra Sharma, Sergio Zanotti, Leo Taiberg, David Gurka, Aseem Kumar, Mary Cheang, Bruce Light, Daniel Roberts. Duration of Hypotension Prior to Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock. Featured Article in Critical Care Medicine Journal 34:1589-1596, 2006. 19. Rama S. Kota, Kapilchandra Gohil, Aseem Kumar , Richard I. Enelow, John C. Rutledge and Chilakamarti.V. Ramana. Regulation of gene expression in RAW 264.7 macrophages by Interferon-gamma. Biochemical and Biophysical Research Communications 342:1137-1146, 2006. 20. Anand Kumar, Aseem Kumar, Bhanu Paladugu, Joel Mensing and Joseph E. Parrillo. TGF- Blocks in-vitro Cardiac Myocyte Depression Induced by TNF- and IL-1 and Human Septic Shock Serum. Featured Article Critical Care Medicine Journal 35:358-364, 2007. 21. Anand Kumar, Bhanu Paladugu, Joel Mensing, Aseem Kumar and Joseph E. Parrillo. Nitric Oxide-Dependent and -Independent Mechanisms are Involved in TNF--Induced Depression of Cardiac Myocyte Contractility. American Journal of Physiology 292:1900-1906, 2007. 22. Danielle Brabant, Paul Michael, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Characterization of Key Apoptotic Signalling Pathways that Mediate Sepsis Induced Cellular Dysfunction, New Cell Apoptosis Research Nova Publishing, Editor. C. Pickens) pages 1-40, July 2007. 23. Majed Halwani, Clement Mugabe, Ali O. Azghani, Robert M. Lafrenie, Aseem Kumar and Abdelwahab Omri. Bactericidal Efficacy of Liposomal Aminoglycosides against Burkholderia Cenocepacia. Journal of Antimicrobial Chemotherapy, 60:760-769, October 2007. 24. Lisa Falvo, Paul Michael, Xiulong Xu, Joseph E. Parrillo, Abdelwahab Omri, Anand Kumar and Aseem Kumar. Human Septic Serum Induced Apoptotic Gene Expression Profile in Human Myocytes. Cell Apoptosis Research Progress, Nova Publishing, Editor: Robert H. Fenton, pages 135-152, May 2008. 25. Marisa Tessier, Paul Michael, Danielle Brabant, Ramana V. Chilakamarti, Abdel Omri, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Characterization of Factors in Human Septic Sera that Mediate Cellular Dysfunction.. Recent Developments in Signal Transduction Research. Research Signpost Editors: Ramana V. Chilakamarti, pages 1-23, May 2008. 26. Majed Halwani, Shanna Blomme, Zacharias E. Suntres, Misagh Alipour, Ali O. Azghani, Aseem Kumar and Abdelwahab Omri. Liposomal Bismuth-Ethanedithiol Formulation Enhances Antimicrobial Activity of Tobramycin. International Journal of Pharmaceutics, 358, 278-284, 2008. 27. Catherine Song, Aseem Kumar, Abdel Omri and Mazen Saleh. Bioinformatics Comparison of Bacterial Secretomes. Genomics, Proteomics and Bioinformatics. 7, 25-36, 2009 28. Bagshaw, S.M. etal. (and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Acute Kidney Injury in Septic Shock: Clinical Outcomes and Impact of Duration of Hypotension Prior to Initiation of Antimicrobial Therapy. Intensive Care Medicine. 35, 871-881, 2009. 29. Shaimaa Hussein, Paul Michael, Amadeo Parissenti, Abdelwahab Omri, Anand Kumar, Joseph E. Parrillo and Aseem Kumar. Late Stage Bacterial Sepsis Induced Gene Profiling. International Journal of Clinical and Experimental Medicine. 2(2), 131-148, 2009. 30. Anand Kumar, Pau Ellis, Yaseen Arabi, Dan Roberts, Bruce Light, Joseph E. Parrillo, Peter Dodek, Gordon Wood, Aseem Kumar, David Simon, Cheryl Peters, Muhammad Ahasan, Dan Chateau. Initiation of Inappropriate Antimicrobial Therapy Results in a 5-fold Reduction of Survival in Human Septic Shock. Chest. 136, 1237-1248, 2009. 31. Chilakamarti V. Ramana, Guang-Shing Cheng, Aseem Kumar, H.J. Kwon and Richard Enelow. Alveolar Epithelial Early Growth Response-1 (EGR-1) Expression Triggered by Activated CD8+ T Cells is Critical for Chemokine Gene Expression and Lung Injury. Molecular Immunology. 47, Issues 2-3, 623-631, 2009. 32. Marya Ahmed, Zhicheng Deng, Shiyong Deng, Aseem Kumar and Ravin Narain. Cationic Glyconanoparticles: Complexation with DNA and Their Cellular Uptake. Bioconjugate Chemistry. 20(11), 2169-2176, 2009. 33. James Crispo, Dominique Ansell, Mathew Piche, Joseph Eibl, Isabella Tai, Aseem Kumar, Gregory Ross and T.C. Tai. Protective Effects of Methyl Gallate on H2O2-induced Apoptosis in PC12 Cells. Biochemical and Biophysical Research Communications. 393, 773-778, 2010. 34. Anand Kumar, Ryan Zarychanski, Bruce Light, Joseph Parrillo, Aseem Kumar, Laura Kravetsky, Steve Doucette and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Critical Care Medicine 38, 1773-1785, 2010. 35. Danielle Brabant, Paul Michael, Ravin Narain, Mazen Saleh, Anand Kumar, Joseph E. Parrillo and Aseem Kumar. Sepsis Mediated Cellular Dysfunction is Mediated by DFF 40 Induced Apoptosis. Biochemical and Biophysical Research Communications. 412, 260-265, 2011. 36. Ismail Cinel, Mustafa Ark, Phillip Dellinger, Tuba Karabacak, Lulufer Tamer, Leyla Cinel, Paul Michael, Shaimaa Hussein, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Involvement of Rho kinase (ROCK) in Lung Injury Induced by Cecal Ligation and Puncture (CLP). Featured Article in J. Thoracic Disease with two editorials. 4, No 1, 30-39, 2012. 37. Farag Bleiblo, Paul Michael, Danielle Brabant, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Bacterial RNA Induces Myocyte Cellular Dysfunction through the Activation of PKR. J. Thoracic Disease. 4, No 2, 114-125, 2012. 38. Emily Rimmer, Anand Kumar, Steve Doucette, Aseem Kumar, Ryan Zarychanski and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Act. Prot.C and Septic Shock: A Propensity-Matched Cohort Study. Critical Care Medicine. 40, No. 11, 2974-2981, 2012. 39. Yaseen Arabi, Saqib Dara, Ziad Memish Abdulmajeed Al-Abdulkareem, Hani M. Tamim, Nehad Al-Shirawi, Joseph E. Parrillo, Stephen Lapinski, Daniel Feinstein, Gordon Wood, Sandra Dial, Anand Kumar and The Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Antimicrobial Therapeutic Determinants of Outcomes in Patients with Cirrhosis-Associated Septic Shock. Hepatology. 56(6). 2305-2315, 2012. 40. Farag Bleiblo, Paul Michael, Danielle Brabant, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. JAK Kinases are Required for the Bacterial RNA and Poly I:C Induced Tyrosine Phosphorylation of PKR. International Journal of Clinical and Experimental Medicine. 6(1):16-25, 2013. 41. Shravan Kethireddy , R. Bruce Light, Yazdan Miranejad , Dennis Maki, YaseenArabi, Stephen Lapinsky, David Simon, Aseem Kumar, Joseph E. Parrillo, Anand Kumar for the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Group. Mycobacterium tuberculosis Septic Shock. Chest 144(2) 474-482, 2013. 42. Yaseen Arabi, Saqib Dara, Kani Tamim, Asgar Rishu, Abdulrazak Bouchama, Mohammad Khedr, Aseem Kumar and Anand Kumar and The Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Clinical Characteristics, Processes of Care and Outcomes in the Obese Patients with Septic Shock: An International Multicenter Cohort Study. Critical Care Journal 17:R72, 2013. 43. Sheryl Zelenitsky, Ethan Rubinstein, Robert Ariano, Harris Iacovides, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Vancomycin Pharmacodynamics and Survival in Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Septic Shock. International Journal of Antimicrobial Agents. 41(13), 255-260, 2013 44. Sandyha Khurana, Amanda Hollingsworth, Matthew Piche, Krishnan Venkataraman, Aseem Kumar, Gregory M. Ross and T.C. Tai. Methyl Gallate Protects Rat Cardiac Myocytes from H2O2-Mediated Apoptosis. Oxidative Medicine and Cellular Longevity Article ID 657512, pages 1-9, 2014. 45. Aleksandra Leligdowicz, Peter M. Dodek, Monica Norena, Hubert Wong, Aseem Kumar, Anand Kumar, and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Association between source of infection and hospital mortality in patients who have septic shock. American Journal of Respiratory and Critical Care Medicine 180:10 pages 1204-1213, 2014. 46. Manish Sood, Keren Mandelzweig, Claudio Rigatto, Navdeep Tangri, Paul Komenda, Gregory Martinka, Yaseen Arabi, Sean Keenan, Aseem Kumar and Anand Kumar for the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group . Non-pulmonary Infections but not Specific Pathogens are Associated with Increased Risk of AKI in Septic Shock. Intensive Care Medicine Vol. 40, Number 8, 1080-1088, 2014. 47. Duane Funk, Steven Doucette, Amarnath Pisipati, Peter Dodek, John C. Marshall, Anand Kumar and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Low Dose Corticosteroid Treatment in Septic Shock: A Propensity Matching Study. Critical Care Medicine 42(11) 2333-2341, 2014. 48. Jason Waechter, Anand Kumar, Stephen Lapinsky, John Marshall, Peter Dodek, Yassin Arabi, Joseph E. Parrillo, Richard Dellinger, Allan Garland and the CATSS Dataase Research Group (Aseem Kumar is a member of this group). Interplay Between Fluids and Vasoactive Agents on Mortality in Septic Shock: A Multicenter, Observational Study. Critical Care Medicine 42(10) 2158-68, 2014. 49. Vance Beck, Dan Chateau, Gregory Bryson, Amarnath Pispati, Sergio Zanotti, Joseph Parrillo, Anand Kumar, and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is member of this group). Timing of Vasopressor Initiation and Mortality in Septic Shock: A Cohort Study. Critical Care 18:R97 pages 1-8, 2014. 50. Manish Sood, Leigh Shafer, Julie Ho, Martina Reslerova, Greg Martinka, Sean Keenan, Sandra Dial, Gordon Wood, Claudio Rigatto, Anand Kumar and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Early Reversible Acute Injury is Associated with Improved Survival in Septic Shock. Journal of Critical Care, Volume 29, Issue 5, 711-717, 2014. 51. Chilakamarti V. Ramana, Matthew DeBerge, Aseem Kumar, Christopher Alia, Joan Durbin and Richard Enelow. Inflammatory Impact of IFN-g in CD8+ T-cell-mediated Lung Injury is Mediated by Both Stat1-dependent and -independent Pathways. American Journal of Physiology, Volume 308, #7, 650-657, 2015. 52. Constantine J. Karvellas, Juan G. Abraldes, Yaseen Arabi, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Appropriate and Timely Antimicrobial Therapy in Cirrhotic Patients with Spontaneous Bacterial Peritonitis-Associated Septic Shock: A Retrospective Cohort Study. Alimentary Pharmacology and Therapeutics. Vol 41:747-757, 2015 53. Heather Peltsch, Sandhy Khurana, Collin Byrne, Phone Nguyen, Neelam Khaper, Aseem Kumar and TC Tai. Cardiac Phenylethanolamine-N-methyltransferase: Localization and Regulation of Gene Expression in the Spontaneously Hypertensive Rat. Canadian Journal of Physiology and Pharmacology. 94:363-372, 2016. 54. Edward Clark, Anand Kumar, Amit Langote, Sean Bagshaw, Manish M. Sood and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Septic Shock in Chronic Dialysis Patients Admitted to the Intensive Care Unit: Clinical Characteristics, Antimicrobial Therapy and Mortality. Intensive Care Medicine. 42:222-232, 2016. 55. Andre Amaral, Robert Fowler, Ruxandra Pinto, Gordon Rubenfeld, Paul Ellis, Brian Bookatz, John Marshall, Greg Martinka, Sean Keenan, Denny Laporta, Daniel Roberts, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Patient and organizational characteristics associated with delays in antimicrobial administration for septic shock. Critical Care Medicine. 44(12):2145-2153, December 2016. 56. Maryam Shojaei, Grant Parnell, David Booth, Anand Kumar, John Ho, Yoav Keynan, Adrienne, Meyers, T Blake Ball, Amarnath Pisapati, Aseem Kumar, Amy Phu, Stephen Huang, Marek Nalos, Anthony S McLean, Kenneth McPhie, Kate O’Connor, Stephen Schibeci and Benjamin M Tang. IFI27 as a biomarker of severe influenza infection. European Respiratory Journal. 49:6, 1602098, 2017. 57. Beverly Kok, Constantine Karvellas, Juan Abraldes, Rajiv Jalan, Vinay Sundaram, David Gurka, Sean Keenan, Aseem Kumar, Greg Martinka, Brian Bookatz, Gordon Wood, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group. The Impact of Obesity in Cirrhoitc Patients with Septic Shock: A Retrospective Cohort Study Liver International. 38:1230-1241, 2018. 58. Anand Kumar, Ryan Zarychanski, Amarnath Pisipati, Aseem Kumar, Shravan Kethireddy and Eric Bow. Fungicidal vs Fungistatic Therapy of Invasive Candida Infection in Non-neutropenic Adults: A Meta-Analysis. Mycology. 9:116-128, 2018. 59. Shravan Kethireddy, Beliz Bilgili, Amanda Bengier, H Lester Kirchner, Uchenna R Ofoma, R. Bruce Light, Yazdan Birzanejad, Dennis Maki, Aseem Kumar, A Joseph Layon, Joseph E. Parrillo and Anand Kumar for the The Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group Culture Negative Septic Shock Compared to Culture Positive Septic Shock: A Retrospective Cohort Study. Critical Care Medicine Journal. 46:4, 506-512, 2018. 60. Jaime Speiser, Constantine Karvellas, Geoff Smoliak, Wendy Sligl, Yazdan Mirzanejad, Dave Gurka, Aseem Kumar, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group. Predicting In-Hospital Mortality in Pneumonia-Associated Septic Shock Patients Using Classification and Regression Tree (CART) Methodology. Journal of Intensive Care, 66:1190 2018. 61. Benjamin Tang, Maryam Shojaei, Sally Teoh, John Ho, Adrienne Meyers, Yoav Keynan, Terry Ball, Amarnath Pisipati, Aseem Kumar, David Booth, Anand Kumar, Anthony McLean and Klaus Schughart. Host Factors Associated with Disease Progression and Fatality in Severe Influenza Infection. Nature Communications. 10: 3422, 2019. 62. Yoann Zerbib, Emily Jenkins, Maryam Shojaei, Adrienne Meyers, John Ho, Blake Ball, Yoav Keynan, Amarnath Pisipati, Aseem Kumar, Anand Kumar, Marek Nalos, Benjamin Tang, Klaus Schughart and Anthony McLean. Pathway Mapping of Leukocyte Transcriptome in Influenza Patients Reveals Distinct Pathogenic Mechanisms Assocated with Progression of Severe Infection. BMC Medical Genomics 13:28, 2020. 63. Paul Michael, Farag Bleiblo, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. STAT1 and STAT2 Null Cells are Resistant to Bacterial RNA-Induced Apoptosis Due to a Deficiency in the Constitutive and Inducible Activation of Apoptosis-Regulating Proteins. American Journal of Molecular Biology 10, 165-187, 2020. 64. Jeremy Lamothe, Sandhya Khurana, Sujeenhar Tharmalingam, Chad Williamson, Collin Byrne, Nellam Khaper, Aseem Kumar and TC Tai. Oxidative Stress Mediates the Fetal Programming of Hypertension by Glucocorticoids. Oxidative Antioxidants 10, 531, 2021 |