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Sujeenthar Tharmalingam, PhD

 

NOSM University
935 Ramsey Lake Road
Sudbury ON Canada P3E 2C6
Email: sutharmalingam@nosm.ca
Assistant Professor, Molecular Biology

Education/Training

2016-2018

 Post-doctoral Fellow, Radiation Biology
NOSM University (Sudbury, Canada)

2014-2015

 Post-doctoral Fellow, Angiogenesis and Vascularisation
Faculty of Health, York University (Toronto, Canada)

2008-2013

 PhD, Cancer Biology and Neuroscience
Department of Pharmaceutical Sciences, University of Toronto (Toronto, Canada)

2005-2008

 B.Sc. Hons, Double Major in Human Biology and Pharmacology
University of Toronto (Toronto, Canada)

Research Investigations

  1. Radiation biology; cancer biology; DNA damage repair;
  2. Molecular mechanisms underlying radiation resistant cancers;
  3. Development of rapid diagnostic platforms for clinical applications;
  4. Expertise: CRISPR gene editing, functional genomics, transcriptomics, epigenetics, proteomics, metabolomics and next-generation sequencing technologies.

Selected Publications

Puukila, S., Tharmalingam, S., Al-Khayyat, W., Peterson, J., Hooker, A. M., Muise, S., Boreham, D. R., and Dixon, D. L. (2021) Transcriptomic Response in the Spleen after Whole-Body Low-Dose X-Ray Irradiation. Radiation research 196, 66-73

Murray, A., Tharmalingam, S., Nguyen, P., and Tai, T. C. (2021) Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero. Scientific reports 11, 20342

MacLean, A., Legendre, F., Tharmalingam, S., and Appanna, V. D. (2021) Phosphate stress triggers the conversion of glycerol into l-carnitine in Pseudomonas fluorescens. Microbiological research 253, 126865

Davidson, C. Q., Tharmalingam, S., Niccoli, S., Nemec-Bakk, A., Khurana, S., Murray, A., Tai, T. C., Boreham, D. R., Khaper, N., and Lees, S. J. (2020) Dose threshold for radiation induced fetal programming in a mouse model at 4 months of age: Hepatic expression of genes and proteins involved in glucose metabolism and glucose uptake in brown adipose tissue. PloS one 15, e0231650

Tharmalingam, S., Khurana, S., Murray, A., Lamothe, J., and Tai, T. C. (2020) Whole transcriptome analysis of adrenal glands from prenatal glucocorticoid programmed hypertensive rodents. Scientific reports 10, 18755

Zarnke, A. M., Tharmalingam, S., Boreham, D. R., and Brooks, A. L. (2019) BEIR VI radon: The rest of the story. Chemico-biological interactions 301, 81-87

Tharmalingam, S., Sreetharan, S., Brooks, A. L., and Boreham, D. R. (2019) Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies. Chemico-biological interactions 301, 54-67

Scott, B. R., and Tharmalingam, S. (2019) The LNT model for cancer induction is not supported by radiobiological data. Chemico-biological interactions 301, 34-53

Pirkkanen, J., Tharmalingam, S., Morais, I. H., Lam-Sidun, D., Thome, C., Zarnke, A. M., Benjamin, L. V., Losch, A. C., Borgmann, A. J., Sinex, H. C., Mendonca, M. S., and Boreham, D. R. (2019) Transcriptomic profiling of gamma ray induced mutants from the CGL1 human hybrid cell system reveals novel insights into the mechanisms of radiation-induced carcinogenesis. Free radical biology & medicine 145, 300-311

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